What is Ferric Pyrophosphate?
Ferric pyrophosphate is an iron coordination entity composed from Fe(3+) cations and diphosphate(4-) anions in a 4:3 ratio. It contains a diphosphate(4-).
Ferric pyrophosphate is an iron replacement product. Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly complexed by pyrophosphate. It presents an increasing interest as this insoluble form can be milder in the gastrointestinal tract and present higher bioavailability.
Product Name : Ferric Pyrophosphate
CAS : 10058-44-3
Molecular Formula : Fe4O21P6
Molecular Weight : 745.21 g/mol
Application of Ferric Pyrophosphate:
Mainly used in food additives (applicable to flour, biscuits, bread, dry mixed milk powder, rice flour, soy milk powder and other products; it is also used in infant formula foods, health foods, convenience foods and functional fruit juice beverages, etc. abroad .), strengthening agents, synthetic fiber fire retardants, anti-corrosion pigments and catalysts. It can be used in dairy products, flour, rice flour, table salt, health products, medicine, etc.
Chemical Properties of Ferric pyrophosphate:
Ferric pyrophosphate (iron(III)pyrophosphate,Fe4(P207)3*xH2O) is a tan or yellowish-white odorless powder or Soluble crystals. It is insoluble in water but is soluble in mineral acids. It is prepared by reacting sodium pyrophosphate with ferric citrate.
Ferric pyrophosphate is an important kind of compounds insoluble in water and also poorly soluble in dilute acid. It does not modify organoleptic characteristics of foods because of its white colour and low reactivity, making it suitable for many difficult-to-fortify food vehicles, such as salt, cereals, infant formulas, and rice. It has been demonstrated to be an effective iron fortificant from efficacy studies. However, the poor solubility of ferric pyrophosphate in gastric juice limits its bioavailability, which furthemore reduces its nutritional value. The relative bioavailability value (RBV) of ferric pyrophosphate was reported to be only about 50% from human studies.
Solubility & Appearance of Ferric Pyrophosphate:
The Increase in solubility for ferric pyrophosphate is attributed to the formation of soluble complexes between Fe (III) and pyrophosphate ions.
The 10 fold increase in the concentration of ionic iron at pH 7 – 8.5, which is close to the pH of the small intestine is expected to be beneficial for enhancing iron bioavailability.
Ferric pyrophosphate is a widely used iron source in food fortification and in nutritional supplements, due to its white color, which is very uncommon for Fe salts.
What is ferric ion complexed by pyrophosphate?
The ferric ion is strongly complexed by pyrophosphate. 1 It presents an increasing interest as this insoluble form can be milder in the gastrointestinal tract and present higher bioavailability.
Aogubio as manufacturer of Ferric Pyrophosphate we hereby state the following facts about the drug:
Ferric pyrophosphate is an iron replacement product intended for the treatment of iron loss or iron deficiency in patients with chronic kidney disease and pregnant ladies. This molecule has a milder gastrointestinal effect compared to other forms of iron supplements
Free iron presents several side effects as it can catalyze the free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly complexed by pyrophosphate having milder gastrointestinal tract effects and present higher bioavailability.
The usage of ferric pyrophosphate is based on the strong complex formation between the two species. Besides, the capacity of pyrophosphate to trigger iron removal from transferrin, enhance iron transfer from transferrin to ferritin and promote iron exchange between transferrin molecules. These properties make it a very suitable compound for parenteral administration, iron delivery into circulation, and incorporation into hemoglobin.
XI’AN AOGU BIOTECH CO.,LTD is devoted into the research and innovation in natural nutritional supplements ingredients. Our own factory and lab with the strict quality control system to ensure quality stability and real price of Ferric pyrophosphate. At the same time, we have our own source for the raw material to make sure the production ability.