Octacosanol is an organic compound with the structural formula CH3 (CH2) 26ch2oh. The appearance is white powder or flake crystal, tasteless and odorless. Soluble in hot ethanol, ether, benzene, toluene, chloroform, dichloromethane, petroleum ether and other organic solvents, insoluble in water. In addition, octacosanol is stable to acid, alkali and reducing agent, stable to light and heat, and is not easy to absorb moisture. Octacosanol belongs to higher fatty alcohol. It is a simple saturated linear alcohol, which is composed of hydrophobic alkyl and hydrophilic hydroxyl. The chemical reaction mainly occurs on the hydroxyl group, which can produce esterification, halogenation, mercaptan, dehydration hydroxylation and dehydration to ether.Aogubio supply high quality octacosanol
Octacosanol (chemical formula: c2h3o) is a natural monobasic higher alcohol, which mainly exists in nature in the form of wax ester. Octacosanol is found in the leaves, stems, fruits or epidermis of many plants such as apple, grape, jujube, alfalfa, sugarcane, wheat and rice. Rice bran wax, sugarcane wax, flax wax, sorghum wax, pea skin wax, insect white wax, beeswax and grape skin wax are all rich in octacosanol, among which rice bran wax is the most abundant.Aogubio supply high quality octacosanol
As a new functional food additive, it has the functions of enhancing physical strength, energy and endurance, improving stress ability, response sensitivity and body metabolic rate, improving myocardial nutrition and oxygen utilization, reducing serum cholesterol and triglyceride content and systolic blood pressure.
Function of octacosanol
In 1937, foreign scholars found that octacosanol had a therapeutic effect on human reproductive disorders. Since 1949, cureton botu of Illinois University in the United States has spent 20 years testing and studying 894 people and 42 projects. The participants in the test include swimming, wrestling, track and field, sports college students, the United States Navy, navy divers and so on. At the same time, with the development of science, a large number of researchers supplemented and verified the functional properties of octacosanol in the later stage. After induction and summary, its main functional properties are as follows:
- Increase endurance, energy and physical strength
Octacosanol is particularly outstanding in enhancing human motor function. Animal experiments show that octacosanol can significantly increase the swimming time of mice. Yu Changqing supplemented the exhausted animals with octacosanol. The experimental results confirmed that it could effectively reduce the MDA level in myocardial mitochondria and prevent the lipid peroxidation of mitochondria. Octacosanol can effectively inhibit the decrease of SOD and GSH PX activities during exhaustive exercise, so as to protect the function of myocardial mitochondria and prevent myocardial injury after exhaustive exercise. In addition, octacosanol was also found to enhance ATP constant in mouse muscle and reduce the content of glycogen in muscle. The experimental results of Huo Junsheng and others show that oral emulsified octacosanol can promote the enzyme activities of PFK, SDH, nadh-t and ATP in mouse myocardium and skeletal muscle, among which the promotion effect on ATPase activity is the strongest, so it can promote the efficient use of ATP. Octacosanol may improve the transfer activity of free fatty acids in muscle, so as to promote the decomposition of lipids and produce energy as an adaptive response to exercise.
- Octacosanol promote lipid decomposition in Hyperlipidemia
In the population trial, after taking octacosanol, the serum cholesterol level and serum low-density lipoprotein cholesterol content decreased significantly, while the content of high-density lipoprotein cholesterol (cholesterol beneficial to human body) remained unchanged, and the weight of fatty tissue around the kidney decreased significantly, but the number of cells did not decrease, indicating that octacosanol can inhibit the accumulation of lipids in the tissue. Octadecanol can also reduce the content of triglycerides in plasma and increase the content of fatty acids. 3. Improve energy metabolism rate and eliminate muscle spasm
Octacosanol can enhance muscle function including myocardium; Reduce systolic blood pressure; Improve myocardial ischemia; Reduce the scope of myocardial injury for the treatment of coronary heart disease. Studies have shown that octacosanol can effectively improve the symptoms of patients with Parkinson’s syndrome.
- Anticoagulantof octacosanol
The study found that the combination of octacosanol and aspirin can synergistically treat cerebral ischemia and thrombosis, and participate in the metabolic pathway of prostaglandins and thromboxanes. Arruzabala et al. Fed SD male rats orally with octacosanol at the dose of 5-20mg / kg and found that octacosanol could inhibit platelet aggregation caused by collagen, that is, the decrease of platelet rescue level and the increase of malondialdehyde concentration in serum. The dose of octacosanol at the dose of 50 ~ 200mg / kg can inhibit the aggregation of platelets caused by ADP in vitro.
- Octacosanol protect the liver
Octadecanol can significantly inhibit the toxicity of hepatocytes induced by galactosamine and thioacetamide. Acute liver injury was induced in rats through CC4, and then octadecanol was administered orally at a dose of 50mg / kg. Compared with the changes of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities and triglyceride content, it was found that octadecanol significantly inhibited the increase of AST and ALT activities in plasma and the increase of TG content in liver, The results showed that octacosanol also had obvious protective effect on CC induced acute liver injury. In addition, octacosanol also has the effects of anti ulcer, improving bone, preventing osteoporosis and stimulating sexual behavior of animals and humans.
Application of octacosanol
In the United States and Japan, octacosanol has been widely used in functional food, nutritional preparations, medicine, cosmetics and high-grade feed, and the market is expanding day by day. In particular, Japan’s research in this field is more in-depth, and China is gradually paying attention to the research and development of octadecanol and its new raw materials, new products, new technologies and new uses.Aogubio supply high quality octacosanol
（1） Application in health food
Octacosanol, as a safe and efficient nutritional supplement, has many biological functions and clinical application value
Value. Its application in health care products mainly comes from its multiple health care functions. Octacosanol can be used to make the following functions
Food: ① sports health care functional food. Octacosanol can not only enhance the energy and endurance of the human body, but also help to lose weight, supplement the energy consumption of athletes and increase the chance of winning.
② It is a health food that helps to treat osteoporosis, high cholesterol and prevent cardiovascular diseases. Octacosanol can reduce the content of excessive calcium and fat in blood. It is an accelerator for the formation of calcitonin. It can be used to treat osteoporosis, high cholesterol and high lipoprotein blood group diseases caused by excessive blood calcium and prevent cardiovascular and cerebrovascular diseases. ⑧ ③ special health food for flight crew. Octacosanol is likely to become an important component of astronauts’ health food. ④ Health food that helps to enhance sexual function. Recent research shows that octacosanol can enhance sexual function in animals and humans.Aogubio supply high quality octacosanol
（2） Application in cosmetics
Octacosanol is used in cosmetics. Its main function is to promote blood circulation, improve oxygen transport capacity and improve basic metabolic rate. At the same time, it can revive cells, enhance skin activity and eliminate skin wrinkles by wiping and absorbing through the skin. So far, 38alkanol has been widely used in cosmetics such as hair conditioner, lipstick and nail polish in Japan. In addition, according to the patent report published in Japan, the mixed alcohol containing octacosanol can significantly improve cell functional activity and has obvious medical effect on alopecia. Human experiments have confirmed that octacosanol is very safe for skin. Natural octacosanol is mainly extracted from various insect wax and plant wax. The common preparation methods include distillation, crystallization, supercritical fluid extraction, molecular distillation and ultrasonic hydrolysis.Aogubio supply high quality octacosanol
（3）Applied in health product field, it is made into capsules
Octacosanol is a world recognized anti fatigue substance. It is extracted from pure natural plant rice bran wax or sugarcane wax and soluble in aliphatic and aromatic compounds at 70-80 º C. The results show that it can not only help to resist fatigue and reduce cholesterol, but also help to relieve alcohol and alleviate the increase of acetaldehyde concentration in blood caused by drinking.
XI’AN AOGU BIOTECH CO.,LTD is devoted into the research and innovation in natural nutritional supplements ingredients. Our own factory and lab with the strict quality control system to ensure quality stability and real price of Octacosanol . At the same time, we have our own source for the raw material to make sure the production ability.