Cooling Agents

Cooling Agents

Infinite Sensations

We are committed to the creation of new products and the discovery of new applications for  existing products.

coolants have been around for decades, the most well-known being menthol. The line offers unique odorless and flavorless cooling sensations which can be used alone or as a complement to menthol to help extend the cool fresh feeling in the final application, or in fruit flavors to enhance juiciness perception. The low volatility of these compounds allows for skin contact without a burning sensation in the eyes. In order to satisfy today’s customers who demand specific sensory experiences, the need exists for physiological coolants to provide intense and memorable sensations.

Exceptional Performance

Fragrance and Sensory Ingredients Business Unit has been a major supplier of the cooling compounds including WS-3, WS-5, WS-12, WS-23 and Menthyl Lactate. These products allow our customers to use coolants in a broader array of market segments and applications.

Our sensory research demonstrates individual coolants are perceived in specific areas of the mouth with different cooling profiles. Each coolant provides unique characteristics in terms of cooling intensity and longevity, combined with negligible odor and low volatility.

Our materials have achieved the requirements  of the Food Safety System Certification 22000.

 Extra  : Enhanced Cooling – Easy-to-use Liquids

Extra WSE-500 combines sensations found in our popular WS-3, WS-23 and Menthyl Lactate with a little something extra.

The  Extra cooling system delivers more. This product provides a balanced and well-rounded cooling sensation with the right intensity for both oral and cosmetic applications.

Extra cooling system is an easy to incorporate liquid. The proprietary cooling system was created without adding solvents or diluting the system. The system is easier to handle than powder, crystals or flakes. These clear liquids allow manufacturers to avoid issues resulting from insufficient mixing of powder.

What are  compounds?

  •    WS-3
  • Cyclohexanecarboxamide,N-Ethyl-5-Methyl-2-(1Methylethyl)-

WS-3 is a menthol derivative.  But unlike menthol, WS-3 is virtually nonvolatile, odorless and tasteless. WS-3 is one of the most used cooling agents in the market and it’s known for its clean immediate cooling impact and has been found to cool primarily at the roof of the mouth, the back of the mouth and the back of the tongue.

  • WS-5
  • N-(Ethoxycarbonylmethyl)-3-p-menthanecarboxamide

WS-5 is a menthol derivative that was developed in the 1970s by Wilkinson Sword, but was not commercialized due to a bitter aftertaste associated with the product. However, we have developed a patented process to offer substantially pure WS-5 that does not possess the bitter aftertaste present in previous forms of the product. WS-5 has been found to have approximately two and one-half times the cooling intensity of WS-3, it is one of the strongest commercially available coolants, yet exhibits a smooth and round flavor profile. WS-5 has been found to cool primarily at the roof of the mouth and the back of the tongue.

  • WS-12
  • (1R,2S,5R)-N-(4-Methoxyphenyl)-5-methyl-2-(1methylethyl)cyclohexanecarboxamide

WS-12 is a menthol derivative. But unlike menthol, WS-12 is virtually nonvolatile, odorless and tasteless. WS-12 offers one of the strongest initial cooling impacts and a significantly longer lasting effect comparing with such conventional coolants such as WS-3, WS-5, and WS-23. It has potential for use in mint flavors in oral care applications as well as confectionary and chewing gum depending on dosage levels. In addition it can be used at low levels to impart freshness into berry, citrus and other fruit flavors in a variety of applications. WS-12 has been found to cool primarily at the front of the tongue.

  • WS-23
  • Butanamide, N,2,3-trimethyl-2-(1-methylethyl)-

WS-23 is not derived from menthol. But like WS-3, it exhibits little or no odor or taste and has a low volatility. Sensory evaluations of WS-23 indicate that the product cools more in the front of the tongue and mouth. While the product has somewhat less cooling impact than that of WS-3, the cooling profile is more round and smooth in character.

  • Extra WSE-500

WSE-500 is a proprietary, liquid blend of cooling agents. This easy to incorporate material allows for manufacturers to avoid issues that result from insufficient mixing of solids.

  •  Menthyl Lactate
  • Propanoic acid, 2-Hydroxy-,5-methyl-2-(1-methylethyl) cyclohexyl ester

Menthyl Lactate is also a menthol derivative. The product has a mild mint-like character, with a fresh and invigorating profile.  In addition to use in flavor applications, the product is also widely used in cosmetics and personal care applications. Our product is offered in fused form.

Cooling Intensity

We have evaluated two basic attributes of cooling agents: cooling at onset and cooling longevity. Sensory attributes of coolants were evaluated at 20 ppm in ethanol. Menthol was used as a reference in measuring the overall cooling intensity.  WS-5 has been found to have approximately four times the cooling intensity of menthol. The desired intensity of sensory perception and duration will depend on factors such as coolant concentration, flavor interactions and other formula attributes.


cooling agents are sparingly soluble in water. They are soluble in ethanol, propylene glycol, flavor systems and fragrance oils.


Solvent Temp.  °C  Solubility, g/100 ml

  • WS-3
Propylene glycol 20 10.7
96% ethanol 20 186.0
40% ethanol 20 0.2
40% ethanol 40 1.2
60% ethanol 20 14.8
60% ethanol 40 38.6
Triacetin 20       Practically insoluble
  • WS- 5
Propylene glycol 20 11.5
96% ethanol 20 79.4
40% ethanol 20 1.9
40% ethanol 40 3.5
60% ethanol 20 50
60% ethanol 40 70
Triacetin 20 Practically insoluble
  • WS-12
Propylene glycol 20 Practically insoluble
96% ethanol 20 0.1
40% ethanol 20 Practically insoluble
60% ethanol 20 0.015
Triacetin 20 Practically insoluble
L-Carvone 20 5.5
Isopropanol 20 2.5
Ethanol (200 Proof) 20 2.5
Ethyl Acetate 20 1.5
  • WS-23
Propylene glycol 20 76.4
96% ethanol 20 260.4
40% ethanol 20 18.8
40% ethanol 40 21.9
60% ethanol 20 101.6
60% ethanol 40 122.2
Triacetin 20 3.6
  • WSE-500
40% ethanol 20 5.6
40% ethanol 40 13.3
60% ethanol 20 62.5
60% ethanol 40 131.6
  • Menthyl Lactate
Triacetin 20 Practically insoluble
Propylene glycol 36.6
96% ethanol 287.3
40% ethanol 20 4.4
40% ethanol 40 7.6
60% ethanol 20 77.0
60% ethanol 40 93.4
Triacetin 28.2

XI’AN AOGU BIOTECH CO.,LTD is devoted into the research and innovation in natural nutritional supplements ingredients. Our own factory and lab with the strict quality control system to ensure quality stability and real price of Cooling Agents. At the same time, we have our own source for the raw material to make sure the production ability.